A $40,000 MRI study led by Jeremy Ethier investigated the popular belief that training a muscle in its stretched position (stretch-mediated hypertrophy) is superior for muscle growth. Using custom machines, the study compared "stretch-focused" versus "squeeze-focused" training for the chest, glutes, side delts, and rear delts in 20 participants over 10 weeks. Utilizing a "within-subjects" design, one side of each person's body did stretch-focused training, and the other did squeeze-focused. The results revealed no significant difference in muscle growth between the two methods for these specific muscles. This indicates that for many muscles, the resistance profile (where the exercise is hardest) isn't the primary factor, as long as full range of motion and some tension in the stretched position are maintained. However, bi-articulate muscles (like hamstrings, quads, triceps) and calves are exceptions that still benefit from being loaded in a deeper stretch. The study concludes that consistent hard training with full range of motion, regardless of resistance profile, allows a wide range of exercises to be effective for growth.