My Experience: Retatrutide Dosage, Side Effects, and Impact on Weight Loss & Physique

Mo Samuels Uncut

Introduction and YouTube Content Restrictions [00:00:00]

The speaker explains that this video will cover details about his 8 kg weight loss in 30 days using the fat loss peptide Retatrutide, information he couldn't include in his previous video due to YouTube's terms and conditions against discussing illicit drugs or substances not approved for human consumption.

• He clarifies that he had to be sarcastic or less direct in the original video to avoid channel deletion.
• He emphasizes that the content is for educational purposes only and not an endorsement or promotion of the substance.

Retatrutide Dosage and Initial Side Effects [00:02:11]

The speaker addresses comments regarding his dosage and side effects.

• Dosage: He states he took the lowest dose used in clinical trials, 1 mg once a week, which is 12 times less than the maximum dose of 12 mg.
• Weight Loss: Over four dosages (30 days), he lost approximately 8 kg.
• Brutal Side Effects:
  • Elevated heart rate by about 8 beats per minute.
  • Severe nausea, occurring unexpectedly days after a dose.
  • An incident of vomiting after a small, fatty meal due to slowed digestion.

    

Understanding Side Effects: Hyper-responder, Product Quality, and Drug Half-Life [00:04:17]

He speculates on why his side effects were so severe despite a low dose.

• 1. Hyper-responder: He believes he might be unusually sensitive to the drug, noting general sensitivity to various substances.
• 2. Product Quality/Incorrect Dose: Since peptides are obtained through unregulated "gray markets" and are not pharmaceutical grade, the actual dosage in the vial might have been significantly higher than labeled (e.g., 15-100 mg instead of 10 mg).
• 3. Drug Half-Life and Build-Up: Retatrutide has a half-life of 6-8 days (average of one week).
  • This means with weekly dosing, the drug accumulates in the system.
  • After one week, 0.5 mg of the initial 1 mg dose remains, so taking another 1 mg results in 1.5 mg total in the body, leading to a compounding effect over time.

    

Minimizing Side Effects: Importance of Dietary Fats [00:06:21]

The speaker highlights a crucial factor for nausea he initially overlooked.

• Role of GLP-1 (Retatrutide): It slows down the movement of food through the stomach.
• Fat Digestion: Fat is the hardest macronutrient to digest.
• Recommendation: Consuming high-fat or fried foods, or large fatty meals, can lead to prolonged stomach retention and severe nausea. Eating lean meals and getting fats from good sources in small amounts can mitigate this.

Impact on Muscle and Bone Density [00:10:02]

He discusses the loss of muscle and bone density associated with weight loss.

• Muscle Loss: He confirms losing muscle during his rapid 8 kg weight loss but states it was intentional to reach a lower target body weight (80 kg).
• Cause of Loss: He explains that muscle and bone density loss, as well as reduced sex drive, are common side effects of any significant calorie deficit, not directly from the drug itself.
• Prevention: To minimize these losses, it's essential to:
  • Engage in resistance training.
  • Consume enough protein.
  • Ensure adequate calorie intake (avoiding extreme deficits).
  • Track macros to maintain a healthy baseline of calories.
• He notes that losing 8 kg in 4 weeks is too rapid and would lead to muscle and bone density loss if sustained.

Defining "Natural" in Fitness and Peptides [00:12:33]

The speaker addresses the "natty vs. not natty" debate in the comments.

• His Definition of "Not Natural": Something that causes long-term changes to physiology or provides an unfair, lasting advantage (e.g., steroids, which increase muscle cell nuclei).
• Peptides vs. Steroids:
  • Steroids cause permanent physiological changes, making one "not natty" even years after stopping.
  • Peptides like Retatrutide do not cause long-term changes to physique; their effects cease once discontinued.
• "Half-Natty" Classification: He considers peptides to put someone in a "half-natty" category, as they provide an immediate advantage while being used, but no lasting changes to the physique. He admits he wouldn't compete in a natural show due to current and past peptide use.

Current Retatrutide Use and Addiction Potential [00:14:56]

The speaker reveals he has resumed taking Retatrutide.

• Current Experience: He is taking 1.5 mg (50% more than before) but experiences no side effects and less significant weight loss, leading him to believe his initial experience might have been due to a higher actual dose or hypersensitivity.
• "Addictive" Nature: He explains that it's "addictive" not chemically, but psychologically, because it offers an incredibly easy path to fat loss, freeing up mental energy usually spent on hunger and dieting discipline.

Previous SARM Use [00:18:20]

He addresses past SARM (Selective Androgen Receptor Modulator) use from over 10 years ago.

• He made a YouTube video taking SARMs for about 2 weeks when he was 19.
• He deleted the video because he was competing in natural shows and didn't want the association, despite natural show clauses often allowing past use after a certain number of years.
• He believes the product he took was likely fake as he experienced no results, only feeling bloated and watery, and supposedly crashed his testosterone. He attributes this to youthful ignorance and doing it "for YouTube."

Reflections on Natural Physique Potential and Discipline [00:21:19]

The speaker emphasizes the significant physique achievable naturally with hard work and good genetics.

• He defends his past natural physique, stating he was polygraphed and drug-tested after competitions.
• He highlights the immense dedication required, mentioning his own routine of 3 hours in the gym, 6-7 days a week, and meticulously tracking macros for almost 10 years.
• He criticizes the tendency to blame external factors rather than one's own efforts or genetics for not achieving desired results.

Additional Side Effects and Their Management [00:25:12]

He clarifies other potential side effects.

• Sex Drive/Energy: Like muscle and bone density loss, reduced sex drive and low energy are consequences of prolonged severe calorie deficits, not direct drug effects. He personally did not experience issues with sex drive.
• Dizziness: He experienced dizziness during training, initially attributing it to low blood sugar (hypoglycemia), but later realizing it was likely due to low blood pressure combined with insufficient food intake. This can be managed by adequate nutrition, hydration, and electrolytes.

Optimal Dosing Frequency: Once vs. Twice a Week [00:26:25]

Based on his anecdotal experience, he discusses dosing frequency.

• He experimented with both once and twice-weekly dosages.
• He found that a single weekly dose (e.g., 1 mg) was more effective for appetite suppression than splitting the dose (e.g., 0.5 mg twice a week).
• He prefers the "oomph effect" of a larger, less frequent dose to activate appetite suppression, noting that splitting the dose resulted in no felt effects.

Final Thoughts and Recommendations [00:27:48]

The speaker provides his concluding thoughts and advice.

• Recommendation: Officially, he cannot recommend the use of Retatrutide due to its illicit nature. However, he acknowledges its potential place in fitness for very overweight individuals.
• Not a Long-Term Solution: He stresses that it is not a long-term solution and prolonged use could lead to future health issues.
• Importance of Natural Habits: He advises that individuals who struggle with dieting or maintaining a lean physique naturally should first acquire the necessary skills (macro tracking, intuitive eating, consistent training) before considering such drugs.
• Potential Use Case: For those who already possess strong self-discipline and knowledge of natural dieting, Retatrutide could be used for short-term cuts or to kickstart motivation when stuck.